This disease can occur anywhere throughout the eastern US, even in a garden with just one cucumber plant and no past occurrences. This is because the pathogen spreads via wind-dispersed spores that can be moved long distances and be deposited by chance anywhere. Cucumber is most commonly affected. Occurrence of downy mildew on melon, squash, pumpkin and other cucurbit types depends on what strain(s) of the pathogen are present. MORE